| Research Area | Projects | Partners | Approach | Publications | Contact |
|---|
Anna-Lena Unterweger, Morten Ø Jensen, Fabrizio Giordanetto, Vishwanath Jogini, Alena Rüscher, Marietta Seuß, Paula Winkelmann, Leandra Koletzko, David E Shaw, Matthias Siebeck, Roswitha Gropp, Florian Beigel, Attila Aszodi. Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanized Mouse Model of Ulcerative Colitis. J Crohns Colitis. 2021 Apr 23 IF=8.7
Paula Winkelmann, Anna-Lena Unterweger, Diya Khullar, Florian Beigel, Leandra Koletzko, Matthias Siebeck, Roswitha Gropp. The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease. Immun Inflamm Dis 2021 May 4. IF=2.6
Henrika Jodeleit, Paula Winkelmann, Janina Caesar, Sebastian Sterz, Lesca M. Holdt, Florian Beigel, Johannes Stallhofer, Simone Breiteneicher, Eckart Bartnik, Thomas Leeuw, Matthias Siebeck, Roswitha Gropp. Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells. Dis Model Mech. 2021 Jan 1; 14(1) IF=4.6
Jodeleit H, Milchram L, Soldo R, Beikircher G, Schönthaler S, AlAmodi O, Wolf E, Beigel F, Weinhäusel A, Siebeck M, Gropp R. Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis. PLoS One. 2020 Feb 12;15(2). IF=2.8
Jodeleit H, Caesar J, Villarroel Aguilera C, Sterz S, Holdt L, Beigel F, Stallhofer J, Breiteneicher S, Bartnik E, Siebeck M, Gropp R. The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ null Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab. Inflamm Bowel Dis. 2019 Nov 29. IF=4.5
Henrika Jodeleit, Omar Al-amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck. Targeting ulcerative colitis by suppressing glucose uptake with ritonavir. Dis Model Mech. 2018 Nov 21;11(11). IF=4.6
Omar Al-amodi, Henrika Jodeleit, Florian Beigel, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp CD1a Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis. Inflamm Bowel Dis. 2018 May 17:1225 IF=4.5
Henrika Jodeleit, Omar Al-amodi, Janina Caesar, Christina Villaroeill Aguilera, Lesca Holdt, Florian Beigel, Roswitha Gropp, Matthias Siebeck, Targeting inflammation by inhibiting glucose uptake. 2018 Zeitschrift für Gastroenterologie 56(08):e200-e201
Jodeleit H, Palamides P, Beigel F, Mueller T, Wolf E, Siebeck M, Gropp R. Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model. J Transl Med. 2017 Dec 28;15(1):265. IF=3.8
Costanza Chiapponi, Maxie Witt, Gabriele E. Dlugosch, Veit Gülberg, Matthias Siebeck. The Perception of Physician Empathy by Patients with Inflammatory Bowel Disease. PLOS ONE 2016 11(11): e0167113. doi: 10.1371/journal.pone.0167113 IF=3.5
Föhlinger M, Palamides P, Mansmann U, Beigel F, Siebeck M, Gropp R. Immunological profiling of UC patients leads to identification of two inflammatory conditions and CD1a as a marker for UC. J Transl Med. 2016 Nov 3;14(1):310. IF=4.2
Palamides P, Jodeleit H, Föhlinger M, Beigel F, Herbach N, Mueller T, Wolf E, Siebeck M, Gropp R. A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals. Dis Model Mech 2016, 9: 985-997. IP=4.9
Jovanovic K, Siebeck M, Gropp R. The route to pathologies in chronic inflammatory diseases characterized by T helper Type 2 immune cells. Clin Exp Immunol 2014, 178(2):201-11. IP=3.2